Weight Maintenance Is Possible After GLP-1s—With the Right Support
Omada Insights Lab shows virtual lifestyle programs may help maintain weight post-GLP-1 discontinuation, with 63.2% of participants maintaining or losing weight after a year.
Though evidence shows that GLP-1s are highly effective for weight loss, maintaining outcomes after GLP-1 discontinuation can be a struggle. Clinical trials indicate that people often regain a considerable amount of weight after discontinuing their GLP-1, with some studies citing up to an average of 67% of weight regained within a year. Given the substantial cost of GLP-1 therapies, weight regain after discontinuation not only jeopardizes health outcomes, it also wastes valuable healthcare dollars.
The question everyone seems to be asking is, “Is weight regain post GLP-1s inevitable?” Can virtual lifestyle programs like Omada help people keep the weight off after GLP-1 discontinuation? And what does the real-world evidence show?
The Omada Insights Lab took on these questions by analyzing weight change up to one year after GLP-1 discontinuation. The sample included 816 members without diabetes enrolled in Omada’s Prevention & Weight Health and Hypertension programs. The analysis found that:
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At 12 months, Omada members largely maintained their weight at GLP-1 discontinuation, with an average 0.8% weight change
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At 12 months, 63.2% of members maintained or continued to lose weight
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At 6 and 9 months, Omada members demonstrated 0.03% and 0.6% average weight change, respectively
These findings suggest that Omada can play an integral role in supporting members during important transitions in their GLP-1 journey, including helping members maintain their weight well after GLP-1 discontinuation.